Effect of salidroside on ventricular remodeling after acute myocardial infarction

Purpose: To investigate the remodeling influence of salidroside (SAL) on ventricles following acute myocardial infarction (AMI) in rats, and processes involved.Methods: A total 65 Sprague Dawley (SD) rats were assigned to 5 groups: sham (n = 13), model, low-, medium- high-dose SAL groups given at doses 12, 34, 36 mg/day, respectively, with 13 each group. Changes pathological structure, collagen area, ratio I/collagen III, left ventricular mass index (LVW/BW), cardiac weight body (HW/BW), creatine kinase MB isoenzyme (CK-MB), lactate dehydrogenase-1 (LDH-1), endothelin (ET), laminin (LN), hyaluronic acid (HA) evaluated. Expression levels dishevelled-1 (DVL-1) β-catenin tissues also determined.Results: The LVW/BW values significantly higher low medium than those AMI while I/III expression DVL-1 proteins lower model group (p < 0.05). structure was normal, no obvious lesions. CK-MB, LDH-1, ET, LN, HA 0.05).Conclusion: Salidroside mitigates by modulating Wnt/β-catenin signal route.